The Cartilage Guide
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03

Peptides

7 entries

Injected, oral, and gray-market peptides with claimed cartilage or joint effects — appraised honestly, including where the literature is thin or absent.

Clinically studied

  • Pentosan polysulfate (PPS)The one compound in this section with real human RCT data — and a phase 3 about to read outPromising

Preclinical & experimental

  • BPC-157Thirty years of rodent healing data, zero human trials, and a single-lab problemPreclinical
  • TB-500 / thymosin beta-4Real ligament and tendon data in rats — and a cartilage signal pointing the wrong wayPreclinical
  • GHK-CuA skin-healing peptide whose single joint study showed a benefit that vanishedPreclinical
  • Peptide "cycles" for joint repairThe stack-and-rotate practice appraised: an evidence pyramid standing on its pointAnecdotal

Bioregulators

  • SigumirA Russian 'cartilage bioregulator' whose evidence base is the institute that sells the conceptAnecdotal
  • CartalaxA synthetic tripeptide with a few cell-culture papers — none of them in cartilage cellsAnecdotal

In this section

  • Clinically studied
  • Preclinical & experimental
  • Bioregulators

How to read the tags.

Strong — multiple RCTs. Promising — early human trials. Preclinical — animal / in-vitro. Anecdotal — community reports. Not supported — trials show no meaningful benefit.

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