A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain (PARA_OA_012)

Paradigm Biopharmaceuticals · ClinicalTrials.gov registration

The pivotal phase 3 trial. Registry checked 2026-08-15: status recruiting (record last updated 2026-05-08), estimated enrolment 466, estimated primary completion July 2027. Company guidance of a top-line readout in early 2027 is not reflected in the registry's own dates.

Population

Adults with knee OA pain; pivotal phase 3, multinational

Intervention

Subcutaneous injectable PPS (Zilosul)

Comparator

Placebo

Limitations

No results yet; sponsor press guidance and registry dates disagree, and the registry is the verifiable source.