Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits

Sebecić B, Nikolić V, Sikirić P, et al. · Bone

Bone healing on radiographic and histomorphometric measures was comparable to autologous bone-marrow or graft treatment.

Population

Rabbits with segmental radial bone defect

Intervention

BPC-157 10 µg/kg locally or 10 µg/10 ng/kg i.m. for 7–21 days

Comparator

Saline; autologous bone marrow; autologous cortical graft

Limitations

Small groups, 1990s methodology, same author network; never advanced to human bone studies.