The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment

Ghosh P · Seminars in Arthritis and Rheumatism

The founding mechanism review: PPS supports chondrocyte anabolism, inhibits catabolic enzymes, normalizes synoviocyte hyaluronan synthesis, and stimulates endothelial release of tissue plasminogen activator while lowering PAI-1 — the proposed route by which a heparinoid could improve subchondral blood flow in OA joints.

Population

Narrative review of PPS pharmacology against OA pathobiology

Intervention

n/a

Comparator

n/a

Limitations

Written by the scientist who developed PPS for arthritis and held commercial interests in it; argues for a disease-modification classification that clinical trials had not — and still have not — confirmed.