Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study

Pavelká K, Gatterová J, Olejarová M, et al. · Archives of Internal Medicine

Replicated the Reginster findings: significantly less joint-space narrowing over 3 years with glucosamine sulfate and modest symptom improvement (Lequesne/WOMAC) versus placebo.

Population

Adults with knee osteoarthritis, Czech Republic

Intervention

Crystalline glucosamine sulfate 1500 mg once daily for 3 years

Comparator

Placebo

Limitations

Also Rottapharm-funded with the same proprietary formulation; same radiographic-methodology concerns as the Lancet trial.