Safety of Cartrophen Vet in the dog: review of adverse reaction reports in the UK

Hannon RL, Smith JG, Cullis-Hill D, Ghosh P, Cawdery MJ · The Journal of Small Animal Practice

An estimated real adverse-reaction incidence of 0.074% per dose even assuming 90% underreporting, dominated by vomiting within minutes of injection and one to two days of lethargy or inappetence — mild and transitory across nine years of UK canine use.

Population

161 suspected adverse-reaction reports for Cartrophen Vet filed with the UK Veterinary Medicines Directorate, 1991–1999

Intervention

Sodium PPS 100 mg/ml veterinary injection in routine canine practice

Comparator

None (pharmacovigilance review)

Limitations

Authored by the manufacturer (Biopharm Australia); passive surveillance underestimates true rates; canine, not human, exposure.