Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI · Biogerontology

Mean lifespan, food intake and body weight were unchanged. Lifespan of the last 10% of survivors rose 13.3% and maximum lifespan 12.3%; chromosome aberrations in bone marrow fell 17.1%; total tumour incidence was unchanged while leukaemia fell six-fold.

Population

Female outbred Swiss-derived SHR mice, 54 per group, from 3 months old to natural death

Intervention

Epitalon (AEDG) 1 µg/mouse subcutaneously, 5 consecutive days each month for life

Comparator

Saline injections on the same schedule

Limitations

A different peptide from Cartalax and nothing to do with joints; the headline mean-lifespan endpoint was null; injected, not oral; Khavinson is a co-author.