Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, Bao CJ, Yan Z, Zhang YQ · World Journal of Gastroenterology

Both routes reduced ulcer area, with inhibition ratios of 45.7–65.6% at 400–800 ng/kg (p<0.01 versus control); the intramuscular route worked at a lower effective dose than the intragastric, and continued dosing rebuilt glandular epithelium and granulation tissue in the chronic model.

Population

Rats with acute (three models) and chronic acetate-induced gastric ulcers

Intervention

BPC 157 200–800 ng/kg intramuscularly or intragastrically

Comparator

Excipient and saline controls, with famotidine as an active reference

Limitations

Independent Chinese group; the paper also reports numerically higher inhibition than famotidine, but no statistical test of that comparison is given in the retrievable record, so the head-to-head is not treated as a finding here.