Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

Wegrowski Y, Maquart FX, Borel JP · Life Sciences

Dose-dependent increase in total glycosaminoglycan synthesis (maximal 10^-9–10^-8 M), mainly dermatan and heparan sulfate — not the aggrecan-type chondroitin sulfate that dominates cartilage.

Population

Cultured human fibroblasts

Intervention

GHK-Cu at graded concentrations

Comparator

Untreated cultures

Limitations

Dermal cells; GAG classes stimulated are skin-matrix, not cartilage-matrix, so extrapolation to cartilage is weak.