Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts

Pollard JD, Quan S, Kang T, Koch RJ · Archives of Facial Plastic Surgery

Shortened population-doubling time in both normal and irradiated lines. Irradiated fibroblasts given GHK-Cu doubled at approximately the rate of untreated normal controls, and produced significantly more bFGF and VEGF early after exposure.

Population

Primary human dermal fibroblasts explanted from patients irradiated for head-and-neck cancer, and non-irradiated controls

Intervention

GHK-Cu 1 nM in serum- and growth-factor-free media

Comparator

Untreated cells of the same lines

Limitations

Cell counts and secreted growth factors only; no matrix or tissue outcome, and the matching in-vivo irradiated-wound experiment (pmid-23744835) was null.