Biotinylated GHK peptide incorporated collagenous matrix: A novel biomaterial for dermal wound healing in rats

Arul V, Gopinath D, Gomathi K, Jayakumar R · Journal of Biomedical Materials Research Part B: Applied Biomaterials

Better contraction, higher cell proliferation and higher antioxidant-enzyme expression than either control. Biotinylated GHK raised copper concentration at the wound site ninefold, which the authors read as the effect being part copper delivery and part matrikine signalling.

Population

Rats with dermal wounds

Intervention

Biotinylated GHK incorporated into a collagen membrane

Comparator

Collagen film alone and untreated wounds

Limitations

Modified peptide in a carrier; the ninefold copper rise makes it hard to separate peptide signalling from local copper loading.