Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study

Bartlett W, Skinner JA, Gooding CR, et al. · The Journal of Bone and Joint Surgery. British Volume

At 1 year both improved similarly (Cincinnati +17.6 vs +19.6); MACI's advantage is surgical simplicity, not proven clinical superiority over membrane ACI.

Population

91 patients randomized to collagen-covered ACI (44) vs matrix-induced ACI (47)

Intervention

MACI (third generation)

Comparator

ACI-C (second generation)

Limitations

1-year follow-up only; underpowered for equivalence; single center.