Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study

Reijman M, Bierma-Zeinstra SMA, Pols HAP, et al. · Arthritis & Rheumatism

Long-term diclofenac use was associated with faster radiologic progression of hip and knee OA; no such signal for most other NSAIDs examined.

Population

Adults ≥55 with hip or knee OA in the population-based Rotterdam Study

Intervention

Long-term diclofenac use (observed, not assigned)

Comparator

Non-users and other NSAIDs

Limitations

Observational — confounding by indication (worse pain → more NSAID use) cannot be excluded.