A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: Periosteum covered versus type I/III collagen covered

Gooding CR, Bartlett W, Bentley G, et al. · The Knee

Clinical results equivalent at 2 years (74% vs 67% good/excellent), but 36.4% of periosteal grafts needed re-operation for graft hypertrophy vs none with collagen — the finding that killed the periosteal flap.

Population

68 patients randomized to ACI with periosteal (33) vs collagen membrane (35) cover

Intervention

ACI with type I/III collagen membrane (second generation)

Comparator

ACI with periosteal flap (first generation)

Limitations

Single-center; 2-year horizon; modest n.