Accelerated healing of excisional skin wounds by PL 14736 in alloxan-hyperglycemic rats

Seveljević-Jaran D, Cuzić S, Dominis-Kramarić M, Glojnarić I, Ivetić V, Radosević S, Parnham MJ · Skin Pharmacology and Physiology

Healing in healthy rats was too fast for either agent to improve; in the delayed-healing hyperglycaemic rats PL 14736 accelerated macroscopic healing dose-dependently, matching becaplermin at the top doses, with more organised granulation tissue — while wound contraction on planimetry was unchanged.

Population

Full-thickness excisional wounds in healthy and alloxan-hyperglycaemic rats, to day 7

Intervention

Topical PL 14736 gel, 10–1,000 µg per wound

Comparator

Becaplermin gel (PDGF-BB) and vehicle

Limitations

Company laboratory; the benefit appears only where healing is already impaired, and the objective planimetry endpoint was null while the macroscopic score moved.