Diminished ciprofloxacin-induced chondrotoxicity by supplementation with magnesium and vitamin E in immature rats

Pfister K, Mazur D, Vormann J, Stahlmann R · Antimicrobial Agents and Chemotherapy

Ciprofloxacin produced typical juvenile cartilage lesions (17 lesions in the standard-diet group); magnesium and vitamin E supplementation cut lesion counts by 41–82% — supporting a chelation/oxidative mechanism for quinolone chondrotoxicity.

Population

48 juvenile Wistar rats

Intervention

Ciprofloxacin with or without magnesium/vitamin E supplementation

Comparator

Ciprofloxacin on standard diet

Limitations

Juvenile rodent model at supratherapeutic exposure; relevance to adult human articular cartilage unproven.