Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial

Budsberg SC, Bergh MS, Reynolds LR, et al. · Veterinary Surgery

PPS-treated dogs recovered ground-reaction forces faster and showed lower cartilage/bone degradation markers at 6 weeks; a genuinely randomized, blinded veterinary trial.

Population

40 client-owned dogs after cranial cruciate ligament surgery

Intervention

PPS 3 mg/kg subcutaneous weekly for 4 weeks post-operatively

Comparator

Placebo injection

Limitations

Veterinary population; modest size; functional gains were on gait measures, not long-term joint outcomes.