Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial

Kalman DS, Heimer M, Valdeon A, et al. · Nutrition Journal

WOMAC pain and some quality-of-life measures improved numerically more with Hyal-Joint, but with n=20 most between-group comparisons were not statistically significant; the authors framed it as hypothesis-generating.

Population

Adults 40+ with knee osteoarthritis, USA

Intervention

Hyal-Joint (chicken-comb extract, 80 mg/day providing ~48 mg hyaluronic acid) for 8 weeks

Comparator

Placebo

Limitations

Tiny pilot (10/group), industry-sponsored, mostly nonsignificant between-group results.