[Effect of peptide regulators on the structural and functional status of bone tissue in ageing rats]

Povorozniuk VV, Khavinson VKh, Makogonchuk AV, Ryzhak GA, Kreslov EA, Gopkalova IV · Advances in Gerontology (Uspekhi Gerontologii)

Both preparations were osteoprotective: given before ovariectomy they blunted the fall in bone mineral density, and given after it they raised density that had already fallen.

Population

Ovariectomised rats, an experimental model of post-menopausal osteoporosis

Intervention

A preparation based on cartilaginous tissue extract — the Sigumir substance — and the substance T-31

Comparator

Untreated ovariectomised rats

Limitations

Bone mineral density, not cartilage; no doses, group sizes or effect sizes in the indexed abstract; Russian-language institute-linked journal and the full text was not retrievable, so the abstract's ranking of the two preparations is not recorded here.