[Effect of peptide regulators on the structural and functional status of bone tissue in ageing rats]

Povorozniuk VV, Khavinson VKh, Makogonchuk AV, Ryzhak GA, Kreslov EA, Gopkalova IV · Advances in Gerontology (Uspekhi Gerontologii)

Both preparations were osteoprotective, and the cartilage extract was significantly the better of the two. Each worked in both directions: given before ovariectomy they blunted the fall in bone mineral density, and given afterwards they raised density that had already fallen.

Population

100 female Wistar rats of 200–230 g, aged 4 to 6 months, in ten groups of ten, most of them bilaterally ovariectomised as a model of post-menopausal osteoporosis

Intervention

A preparation made from an extract of calf cartilage tissue, at 1 mg or 0.03 mg per rat, and the short-peptide preparation T-31 at 10 µg or 0.3 µg per rat, both injected intramuscularly daily for one month — either the first or the second month after ovariectomy

Comparator

Ovariectomised rats given nothing, and a non-ovariectomised control group

Limitations

Bone mineral density, not cartilage. The route is intramuscular injection, where the product this is read as evidence for is an oral capsule. The paper calls its test article a preparation based on an extract of calf cartilage and does not name Sigumir, so the identification is ours and not the authors'. Russian-language journal tied to the originating institute.