Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone

Krivic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P · Inflammation Research

BPC 157 raised the Achilles functional index at every time point (p<0.05) while lowering myeloperoxidase activity and raising the vascular index. Methylprednisolone matched the anti-inflammatory effect but suppressed new vessel formation and left functional recovery unchanged, separating the two effects.

Population

Wistar albino rats, Achilles tendon-to-bone transection, days 1–4

Intervention

BPC 157 10 µg/kg i.p. once daily from 30 min post-surgery

Comparator

Methylprednisolone 5 mg/kg i.p., and saline

Limitations

Four-day window, before collagen healing begins, so it measures early function rather than repair strength; originating Zagreb network.