Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N · Cell Metabolism

Named its own limit in its title. Resveratrol reproduced dietary-restriction gene-expression patterns and reduced signs of ageing — less albuminuria, less vascular inflammation and apoptosis, greater aortic elasticity, better motor coordination, fewer cataracts, preserved bone mineral density — but standard-diet mice given resveratrol from midlife did not live longer.

Population

Mice on a standard diet, treated from 12 months of age

Intervention

Dietary resveratrol

Comparator

Standard diet

Limitations

Mouse; treatment began in midlife. The clean statement of the healthspan-versus-lifespan distinction that the marketing around this compound tends to blur.