Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N · Cell Metabolism

Named its own limit in its title. Resveratrol reproduced dietary-restriction gene-expression patterns across several tissues and reduced signs of ageing: less vascular inflammation and apoptosis, greater aortic elasticity, better rotarod performance, fewer cataracts, and higher trabecular tissue mineral density and bone volume fraction in standard-diet mice. The albuminuria finding belongs to the high-calorie arms — those mice were protected from a rise the standard-diet controls never had. Standard-diet mice given resveratrol from 12 months of age did not live longer.

Population

Mice on a standard diet and on a high-calorie diet, each with and without resveratrol, treated from 12 months of age

Intervention

Dietary resveratrol

Comparator

Standard diet

Limitations

Mouse; treatment began in midlife, and the endpoints are spread across diet groups rather than all measured in one. Its bone measurements are its closest approach to a musculoskeletal endpoint, and they are femurs, not joints.