Copper-GHK increases integrin expression and p63 positivity by keratinocytes

Kang YA, Choi HR, Na JI, Huh CH, Kim MJ, Youn SW, Kim KH, Park KC · Archives of Dermatological Research

Increased keratinocyte proliferation; basal cells became cuboidal, and integrin α6 and β1, p63 and PCNA positivity all rose, confirmed by western blot. The authors read the p63 rise as support for basal stem-cell survival.

Population

Monolayer human keratinocytes and three-dimensional skin-equivalent models

Intervention

Copper-GHK added to culture

Comparator

Untreated cultures and skin equivalents

Limitations

Epidermal, not mesenchymal or chondral. Marker expression in a skin equivalent, with no functional repair endpoint.