Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Ruff KJ, Winkler A, Jackson RW, et al. · Clinical Rheumatology

NEM produced statistically significant reductions versus placebo in pain (about 15-22% mean reduction at days 10-60) and stiffness (about 27% at day 60); absolute effects were modest and roughly a third of patients were non-responders.

Population

Adults with knee osteoarthritis, USA

Intervention

Natural eggshell membrane (NEM) 500 mg once daily for 8 weeks

Comparator

Placebo

Limitations

Sponsored by ESM Technologies (NEM's maker) with a company author; small trial; supplement-grade endpoints over 8 weeks only.