Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Gjurasin M, Miklic P, Zupancic B, Seiwerth S, Sikiric P, et al. · Regulatory Peptides

Faster axonal regeneration on histomorphometry (larger myelinated-fibre diameter, thicker myelin, more fibres per area, more vessels), higher motor action potentials on EMG at one and two months, better sciatic functional index, and absent autotomy.

Population

Rats with transected sciatic nerve, anastomosed or with a 7 mm segment resected and tubed

Intervention

BPC 157 10 µg/kg or 10 ng/kg intraperitoneally, intragastrically, locally at the anastomosis, or into the tube

Comparator

Untreated transection

Limitations

Originating network; four delivery routes reported as concordant, which reduces the discriminating value of any one arm.