Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells

Ghosh P, Wu J, Shimmon S, et al. · Arthritis Research & Therapy

PPS at 2.5 µg/mL stimulated proteoglycan synthesis ~130% and drove type II collagen deposition while suppressing osteogenic drift — a plausible cartilage-anabolic mechanism.

Population

Adult human bone-marrow mesenchymal precursor cells

Intervention

PPS 0–20 µg/mL in culture up to 10 days

Comparator

Untreated cultures; hyaluronan, heparin, dextran sulfate

Limitations

Cell culture; authors linked to PPS commercialization.