Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application

Pevec D, Novinscak T, Brcic L, Seiwerth S, Sikiric P, et al. · Medical Science Monitor

Methylprednisolone markedly worsened healing; BPC 157 given by either route restored function and histology in corticosteroid-treated animals at every assessed interval, the authors reporting complete reversal of the corticosteroid impairment.

Population

Rats with crushed gastrocnemius, with and without systemic 6α-methylprednisolone

Intervention

BPC 157 i.p. or as a topical cream, once or once daily to day 14

Comparator

Corticosteroid alone, and untreated crush

Limitations

Originating network; 'complete reversal' is the authors' characterisation of functional and histological scores, not a quantified biomechanical endpoint.