Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A · The American Journal of Clinical Nutrition

Frontal-cortex blood flow rose dose-dependently during cognitive tasks, with increased deoxyhaemoglobin suggesting greater oxygen extraction. Cognitive performance itself was not affected at either dose.

Population

Healthy adults

Intervention

Single doses of 250 mg and 500 mg trans-resveratrol, counterbalanced crossover

Comparator

Placebo

Limitations

Acute single doses in 22 healthy young adults; near-infrared spectroscopy is an indirect measure of blood flow. A physiological effect without a functional one.