[Morphological characteristics of bone tissue regeneration process in young and old animals]

Kurilov IN, Ryzhak GA · Advances in Gerontology (Uspekhi Gerontologii)

Repair was markedly slower with age: the bony sleeve closed by about day 28 in the young rabbits and day 35 in the old, with marrow structure appearing a week later in old animals at each stage. Placing the cartilage-and-bone extract into the defect accelerated repair in the old animals.

Population

13 chinchilla rabbits — 5 aged two years at 1.5 to 2.0 kg and 8 aged five years at 4.5 to 5.0 kg — with a through-defect in the femur holding a 0.5 cm Teflon fistula, a 2 mm by 5 mm tunnel walled by bone, so that marrow migrating into it could be followed

Intervention

0.2 ml of an extract of cartilage and bone from 14-day chick embryos, placed into the defect in three of the eight old rabbits

Comparator

The remaining old rabbits, and the young rabbits as the age reference

Limitations

Three treated animals, and the acceleration is described from histology rather than measured or tested — the paper reports no statistics at all. The extract is avian and embryonic, placed directly into a bone defect, which is neither the bovine preparation, the oral course nor the joint this is read alongside. Russian-language journal tied to the originating institute.