[Use of Bioimplants to Replace Cartilage Part I: Chondrocyte Cultivation in Three-dimensional Gel.]

Pesáková V, Adam M · Acta Chirurgiae Orthopaedicae et Traumatologiae Čechoslovaca

Three-dimensional culture preserved the chondrocyte phenotype, and the authors attribute that preservation to aggrecan rather than to GHK. The constructs formed a firm net-like tissue subsequently implanted as a cartilage graft.

Population

Pig chondrocytes in three-dimensional culture with cartilage collagens

Intervention

Medium with cartilage collagens plus aggrecan, plus GHK tripeptide, or plus both

Comparator

Cartilage collagens alone

Limitations

Czech-language report with an English abstract only; GHK was one of four medium conditions and no separate GHK effect size is given. No blinding, no replicate counts in the abstract.