Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT

Sawitzke AD, Shi H, Finco MF, et al. · Annals of the Rheumatic Diseases

Over 2 years no treatment arm, including celecoxib, was significantly better than placebo on WOMAC pain or function; odds of response for glucosamine+chondroitin were similar to placebo.

Population

GAIT participants with knee OA who continued blinded treatment for 2 years

Intervention

Glucosamine HCl 1500 mg/day, chondroitin 1200 mg/day, both, or celecoxib for 24 months

Comparator

Placebo

Limitations

Substantial dropout from the original cohort; wide confidence intervals mean modest effects cannot be fully excluded.