Multifunctionality of the beta-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing

Husson C, Cantrelle FX, Roblin P, Didry D, Le KH, Perez J, Guittet E, Van Heijenoort C, Renault L, Carlier MF · Annals of the New York Academy of Sciences

β-thymosins are moderate-affinity G-actin sequesterers whose effect on the filament pool is amplified by shifting the critical concentration for assembly; closely related WH2 domains instead support filament growth, nucleation and severing, so the same short module can push actin in opposite directions depending on context.

Population

Structural and biochemical review of β-thymosin/WH2 actin-binding domains

Intervention

n/a

Comparator

n/a

Limitations

Structural review; no tissue or organism outcomes.