Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis

Ohara H, Iida H, Ito K, Takeuchi Y, Nomura Y · Bioscience, Biotechnology, and Biochemistry

Pro-Hyp stimulated hyaluronic acid production in cultured synovium cells and was detectable in guinea pig blood after oral collagen hydrolysate. Orally administered hydrolysate increased proteoglycan content in the epiphyses and reduced the morphological changes of osteoarthritic cartilage destruction in the knee.

Population

Cultured synovium cells, plus a guinea pig model of osteoarthritis

Intervention

Pro-Hyp in vitro; oral collagen hydrolysate in vivo

Limitations

A four-sentence short communication reporting no effect sizes, no group sizes and no statistics in the abstract. Authors are at Meiji Seika Kaisha, a food company. Guinea pig model; the in-vitro arm may be subject to the fetal-bovine-serum Pro-Hyp contamination issue later identified in pmid-31905705.