The role of mitochondria in osteoarthritis

Blanco FJ, Rego I, Ruiz-Romero C · Nature Reviews Rheumatology

Human OA chondrocytes show reduced electron-transport-chain Complex I, II, and III activity versus normal chondrocytes, and mitochondrial dysfunction plausibly feeds oxidative stress, cytokine-driven catabolism, matrix calcification, and chondrocyte apoptosis — the rationale for testing mitochondria-targeted drugs in joints.

Population

Narrative review of mitochondrial biology in human OA chondrocytes

Intervention

n/a

Comparator

n/a

Limitations

Establishes the drug target, not any treatment; no SS-31 content.