Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions

Ilic S, Drmic D, Franjic S, Seiwerth S, Sikiric P, et al. · Life Sciences

Diclofenac alone produced gastric, intestinal and liver lesions, raised bilirubin, AST and ALT, enlarged the liver and caused hepatic encephalopathy with cortical and cerebellar oedema and damaged neurons; both BPC 157 routes antagonised the whole cluster.

Population

Rats given diclofenac 12.5 mg/kg i.p. daily for three days

Intervention

BPC 157 10 µg/kg or 10 ng/kg i.p., or per-orally in drinking water (0.16 µg/mL or 0.16 ng/mL)

Comparator

Diclofenac alone

Limitations

Originating network; a supratherapeutic NSAID dose, so it models toxicity rather than the routine analgesic use a reader would have in mind.