Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study

Debbi EM, Agar G, Fichman G, et al. · BMC Complementary and Alternative Medicine

Small but statistically significant improvements in WOMAC physical function and total score versus placebo; WOMAC pain improved within the MSM group but gains were modest, and the authors questioned whether they were clinically meaningful.

Population

Adults with radiographic knee osteoarthritis, Israel

Intervention

MSM 1.125 g three times daily (3.375 g/day) for 12 weeks

Comparator

Placebo

Limitations

Small trial, short duration; authors explicitly flagged uncertain clinical relevance of the small effect.