[The geroprotective effect of the amino acids and tripeptides in the cartilage tissue culture in rats]

Smirnov AV, Chalisova NI, Ryzhak GA, Kontsevaia EA, Voĭtsekhovskaia MA · Advances in Gerontology (Uspekhi Gerontologii)

The number of amino acids that stimulated proliferation fell six-fold in explants from old rats, while the tripeptides stimulated proliferation in explants from both young and old animals.

Population

Organotypic cartilage explant cultures from 3-month-old and 24-month-old rats

Intervention

20 coded amino acids and synthetic bioregulatory tripeptides at 0.05 ng/ml

Comparator

Untreated explants

Limitations

The indexed abstract does not say which tripeptides were tested, so AED cannot be confirmed as one of them; Russian-language institute-linked journal; proliferation area only, no matrix endpoint.