Dietary advanced glycation end products and aging

Luevano-Contreras C, Chapman-Novakofski K · Nutrients

Reviews what is known about the dietary route specifically: a portion of ingested AGEs is absorbed — it cites roughly a tenth of the immunoreactive AGEs eaten, two-thirds of that retained in tissue — dietary restriction lowers circulating AGEs and markers of oxidative stress and inflammation in human studies, and the endpoints tested have been metabolic and renal rather than musculoskeletal.

Population

Human and animal studies of dietary AGE intake

Intervention

Higher or restricted dietary AGE intake

Comparator

Usual intake

Limitations

Narrative review with no joint-outcome study in it; rheumatoid arthritis appears only in a list of conditions associated with AGE accumulation. University of Illinois and Mexican CONACYT support.