The sirtuin SIRT6 regulates lifespan in male mice

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L · Nature

Male Sirt6-overexpressing mice lived significantly longer than wild-type; female mice showed no lifespan gain. Long-lived males had lower serum IGF-1 and altered IGF-1 signalling.

Population

Transgenic mice overexpressing Sirt6

Intervention

Sirt6 overexpression

Comparator

Wild-type littermates

Limitations

One sex only, one mouse background, one laboratory; SIRT6 is not the sirtuin resveratrol or NMN is marketed against.