Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation

Miller DM, DeSilva D, Pickart L, Aust SD · Advances in Experimental Medicine and Biology

GHK:Cu inhibited lipid peroxidation only when the iron source was ferritin, by blocking iron release from ferritin channels. It showed no significant superoxide-dismutase-like or ceruloplasmin-like activity — a narrower antioxidant mechanism than the general claim.

Population

Cell-free iron-catalysed lipid peroxidation systems

Intervention

GHK:Cu(II)

Comparator

Alternative iron sources; superoxide dismutase and ceruloplasmin as reference activities

Limitations

Cell-free chemistry with no tissue endpoint; useful mainly for bounding what 'antioxidant' means for this molecule.