Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial

Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A · Journal of Agricultural and Food Chemistry

Significant reduction in VAS pain at day 70 (p < 0.001) and in WOMAC at both day 35 (p = 0.017) and day 70 (p < 0.001), with improved physical activity. Tolerability equalled placebo. Matters here as the closest clinical analogue to eating chicken joint cartilage: it is the same tissue class as the cartilage in chicken feet.

Population

Adults with physician-verified progressive hip and/or knee osteoarthritis, pain >=3 months, Physician Global Assessment >=4

Intervention

2 g/day BioCell Collagen — hydrolyzed chicken sternal cartilage extract containing type II collagen, chondroitin sulfate and hyaluronic acid — for 70 days

Comparator

Placebo

Limitations

Single 70-day trial with no independent replication. First author is at AIBMR Life Sciences, a contract research organisation serving the supplement industry, and the product is a trademarked commercial ingredient. Symptom endpoints only, no imaging.