Dietary polyphenols and mechanisms of osteoarthritis

Shen CL, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS · The Journal of Nutritional Biochemistry

The reference map for how food polyphenols are supposed to act on a joint: suppression of IL-1β signalling, NF-κB, MMPs and aggrecanases in chondrocytes, and of osteoclast activity in subchondral bone. Reads across compounds, which is what makes it useful and also what makes it non-specific.

Population

Cell, animal and human studies of dietary polyphenols in osteoarthritis

Intervention

Dietary polyphenols — green tea catechins, pomegranate tannins, resveratrol and others

Comparator

Not applicable

Limitations

A mechanistic review from 2012; the clinical literature it anticipated has largely not arrived.