Stem cell recovering effect of copper-free GHK in skin

Choi HR, Kang YA, Ryoo SJ, Shin JW, Na JI, Huh CH, Park KC · Journal of Peptide Science

Copper-free GHK reproduced the copper-GHK findings — higher proliferation, linear α6 and β1 integrin staining along the basement membrane, and more p63- and PCNA-positive cells. The tripeptide has activity in this model without added copper.

Population

Normal human keratinocytes and skin-equivalent models

Intervention

Copper-free GHK

Comparator

Untreated cultures; the group's own earlier copper-GHK results

Limitations

Single laboratory comparing against its own historical copper-GHK data rather than a head-to-head arm; epidermal endpoints only.