Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance

Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB · Cell Metabolism

NULL, and mechanistically so. Plasma resveratrol rose, but body composition, resting metabolic rate, lipids and inflammatory markers were unchanged, hyperinsulinaemic-euglycaemic clamp showed no gain in liver, muscle or adipose insulin sensitivity, and the putative molecular targets — AMPK, SIRT1, NAMPT, PPARGC1A — were unaffected in muscle and fat biopsies.

Population

Non-obese postmenopausal women with normal glucose tolerance

Intervention

Resveratrol 75 mg/day for 12 weeks

Comparator

Placebo

Limitations

A healthy population with little room to improve, and a low dose. The value of the record is the target engagement measurement: the pathway resveratrol is sold on did not move.