Vitamin K deficiency is associated with incident knee osteoarthritis

Misra D, Booth SL, Tolstykh I, et al. · The American Journal of Medicine

Subclinical vitamin K deficiency predicted incident radiographic knee OA (RR 1.56, 95% CI 1.08-2.25) and incident MRI cartilage lesions (RR 2.39, 95% CI 1.05-5.40).

Population

MOST study participants without knee OA at baseline, mean age 62, 62% women, 30-month follow-up

Intervention

Baseline plasma phylloquinone; no intervention

Comparator

Vitamin K sufficient participants

Limitations

Observational; single baseline K measurement; residual confounding by diet and health behaviours.