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Cohort · 2013 · n=1,180

Vitamin K deficiency is associated with incident knee osteoarthritis

Misra D, Booth SL, Tolstykh I, et al. · The American Journal of Medicine

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Subclinical vitamin K deficiency predicted incident radiographic knee OA (RR 1.56, 95% CI 1.08-2.25) and incident MRI cartilage lesions (RR 2.39, 95% CI 1.05-5.40).

Population
MOST study participants whose knees were free of radiographic OA at baseline (1,340 knees), mean age 62, 62% women, 30-month follow-up
Intervention
Baseline plasma phylloquinone; no intervention
Comparator
Vitamin K sufficient participants
Limitations
Observational; single baseline K measurement; residual confounding by diet and health behaviours.

Cited by

2 entries reference this study

  • Vitamin K2 (MK-7)

    Supplements → Vitamins & cofactors · key study

    PROM.
  • Vitamin K from greens

    Foods & Nutrition → Nutrients & minerals from food

    PROM.