Thymosin β4 enhances the healing of medial collateral ligament injury in rat

Xu B, Yang M, Li Z, et al. · Regulatory Peptides

Better-organized collagen fibrils and significantly improved biomechanical properties of the healing ligament at 4 weeks.

Population

Rats with transected medial collateral ligament

Intervention

1 µg thymosin β4 in fibrin sealant placed in the ligament gap at surgery

Comparator

Fibrin sealant alone

Limitations

Single small study; local surgical delivery, not the systemic injections used by the gray market.