Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis

Ko JY, Choi YJ, Jeong GJ, Im GI · Biomaterials

Included as the counter-example to the dietary route: when investigators wanted a reliable sulforaphane concentration in a joint, they injected it in a slow-release carrier rather than feeding it. That choice is itself a statement about how much reaches cartilage from a meal.

Population

Animal osteoarthritis model

Intervention

Sulforaphane in slow-release PLGA microspheres, injected into the joint

Comparator

Vehicle injection

Limitations

Intra-articular delivery of a formulated microsphere has no dietary equivalent.