Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

Matsuzaki T, Matsushita T, Takayama K, et al. · Annals of the Rheumatic Diseases

Loss of the NAD+-dependent deacetylase SIRT1 in chondrocytes accelerated OA progression with ageing and under mechanical stress, with increased chondrocyte apoptosis — establishing the pathway NMN supplementation is hypothesised to support.

Population

Chondrocyte-specific Sirt1 conditional knockout mice (ageing and surgical-instability OA models)

Intervention

Genetic deletion of Sirt1 in cartilage

Comparator

Wild-type littermates

Limitations

Genetic loss-of-function model; shows the pathway matters, not that raising NAD+ orally protects human cartilage.