The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin

Birk AV, Liu S, Soong Y, et al. · Journal of the American Society of Nephrology

Demonstrated that SS-31 binds cardiolipin with high affinity, inhibits the cytochrome c peroxidase activity that damages mitochondria during ischemia, protects cristae membranes, and accelerates ATP recovery on reperfusion — the core mechanism paper, in kidney, not joint tissue.

Population

Rats with renal ischemia-reperfusion injury; isolated mitochondria and cell systems

Intervention

SS-31 pretreatment; fluorescent-analog binding studies

Comparator

Untreated ischemic controls

Limitations

Renal ischemia model from the originating (Szeto) lab; establishes mechanism, not any joint effect.