Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition

Jevsevar DS · The Journal of the American Academy of Orthopaedic Surgeons

The 2013 AAOS guideline could not recommend hyaluronic acid for symptomatic knee OA — a STRONG recommendation against, based on meta-analysis showing effects below clinical significance thresholds.

Population

AAOS evidence-based guideline, second edition

Intervention

Guideline recommendations for knee OA treatment

Limitations

Superseded by the 2021 third edition, which softened the wording to a moderate recommendation against routine use.