Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

Lugo JP, Saiyed ZM, Lau FC, et al. · Journal of the International Society of Sports Nutrition

UC-II increased average knee-extension range of motion versus placebo (81.0 vs 74.0 degrees at day 120) and lengthened time to exercise-induced knee pain; joint pain at rest did not differ.

Population

Healthy adults without OA who developed knee pain during a standardized stepmill test

Intervention

UC-II 40 mg/day for 120 days

Comparator

Placebo

Limitations

Small industry-funded trial in healthy people; ROM is a surrogate outcome of uncertain clinical meaning.